Several 2025 studies from Baylor College of Medicine and Emory University provide the first experimental evidence that psilocybin and its active metabolite, psilocin, can extend biological lifespan — at least in cells and animal models. These findings appear in the peer-reviewed journal npj Aging (a Nature Partner Journal) and several associated summaries.
- While it’s not proven whether humans and mice would react the same, they often do.
. - While it’s not proven that it would work with small doses throughout the month–the studies used one large injection each month–it might well work the same.
. - Testing on cells in a petri dish, the cells showed slower senescence, preserved telomere length, reduced oxidative stress, and increased longevity markers.
. - Testing on aged mice (equivalent to 60–65-year-old humans), the psilocybin treatment led to 30–50% improved survival rates versus controls after 10 months. Treated mice also appeared biologically younger—healthier fur, fewer white hairs, and improved vitality.
How Much for a Human to Take?
The amounts in these studies translate to about 3-4 mg per day for a human weighing 165 pounds. That would be 3mg if you took a dose each day, and 4mg if you took it only on weekdays. It’s uncertain whether they gave the mice ground up magic mushrooms or whether they used some purified form of psilocybin.
Would it Make you Stoned?
If you’re microdosing, taking, for example, 30 to 40 hundredths of a gram of mushrooms would be somewhat high for a microdose, but not unheard of. Most folks who microdose want to AVOID being stoned. I think this amount might be wandering into the stoned area. But, of course, a a person could find out about that pretty easy.
🙂
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